Ameela Polynucleotides | Ameela Skin

ABOUT AMEELA®

AMEELA POLYNUCLEOTIDE

Amedica Group is the first-to-market and longest-running distributor of injectable polynucleotides, having proudly announced the launch of Ameela polynucleotide in June 2023 (previously known as Nucleadyn).

Ameela polynucleotides are extracted from salmon DNA and purified at high temperatures, which is a ground-breaking approach to regenerative medicine. This unique treatment ensures the recovery of a >95% pure active substance, free from proteins and hormones, guaranteeing product safety and the absence of immunological side effects. This innovative solution effectively restores skin firmness and elasticity, protecting the skin against free radicals and cellular damage.

When Ameela is injected, it connects with multiple cell receptors, initiating a cascade of reactions (most importantly attracting stem cells to the injected area, which has a strong repairing effect on the tissue, enhancing the formation of new capillaries (angionesis)). In addition, Ameela changes the structure of the fibrilles in our tissue which results in instant tightening and contouring of the tissue, as well as the maturation of fibroblasts in myofibroblasts. The production of collagen gives a strong, specific lifting and revitalizing effect that is suitable for all skin types.

MECHANISMS OF AMEELA®

DEEP TISSUE STIMULATION WITH AMEELA POLYNUCLEOTIDES

MECHANISMS OF ACTIONS OF AMEELA Synergy of four effects for skin:

- Moisturising effect

- Bio-stimulating effect

- Detoxifying effect against free radicals

- Contouring and tightening

Ameela stimulates cell growth, tissue repair, the production of proteins present in the extracellular membrane and reduces inflammation and pain processes through the activation of adenosine A2A receptor1.

Ameela key effects include:

- stimulation of A2 adenosine receptors;

- wound healing (through stimulating proliferation of fibroblasts and increasing the synthesis of collagen);

- anti-inflammation (by reducing the expression of pro-inflammatory cytokines);

- stimulation of blood flow, which aids in tissue healing and tissue regeneration; and osteoblast growth stimulation.

BENEFICIAL EFFECTS

Ameela has a:

- hydrating effect, thanks to the ability of the polynucleotide matrixes of binding water and directing it three-dimensionally in the tissue.

- long term antioxidant effect, thanks to the chemical structure able to absorb free radicals by blocking the effects of these carriers at cellular level.

- stimulating effect at fibroblastic level (receptor activation (CD39 e CD 40) increases the production of collagen of type 1).

- important effect related to the increase both in the number and metabolic activity of fibroblasts, the main cells that preside over the continuous renewing of the several dermal components.

- metabolic effect on assert cells; polynucleotides contribute to the reintegration of several fundamental autologous which help maintain physiological functionality.

Ameela also improves the thickness and quality of the skin (stimulating collagen and elastin production) and deep tissue, reduces the degradation of the bone matrix and promotes a homogeneous redistribution of the adipose tissue.